Gilles Thomas Research Scientist/Engineer - Senior gthomas@apl.washington.edu Phone 206-221-4590 |
Education
M.S. General Engineering, Ecole Centrale de Nantes, 2014
M.S. Mechatronic Engineering, Universidade de Sao Paulo, 2014
M.S. Mechatronic Engineering, Universidade de Sao Paulo, 2015
Ph.D. Biomedical Engineering, Universite Lyon, 2019
Publications |
2000-present and while at APL-UW |
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Advancing boiling histotripsy dose in ex vivo and in vivo renal tissues via quantitative histological analysis and shear wave elastography Ponomarchuk, E., G. Thomas, M. Song, Y.-N. Wang, S. Totten, G. Schade, J. Thiel, M. Bruce, V. Khokhlova, and T. Khokhlova, "Advancing boiling histotripsy dose in ex vivo and in vivo renal tissues via quantitative histological analysis and shear wave elastography," Ultrasound Med. Biol., 50, 1936-1944, doi:10.1016/j.ultrasmedbio.2024.08.022, 2024. |
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1 Dec 2024 ![]() |
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Objective |
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Histotripsy-induced bactericidal activity correlates to size of cavitation cloud in vitro Ambekar, P.A., Y.-N. Wang, T.D. Khokhlova, G.P.L. Thomas, P.B. Rosnitskiy, K. Contreras, D.F. Leotta, A.D. Maxwell, M. Bruce, S. Pierson, S. Totten, Y.N. Kumar, J. Thiel, K.T. Chan, W.C. Liles, E.P. Dellinger, A. Adedipe, W.L. Monsky, and T.J. Matula, "Histotripsy-induced bactericidal activity correlates to size of cavitation cloud in vitro," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 71, 1868-1878, doi:10.1109/TUFFC.2024.3476438, 2024. |
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9 Oct 2024 ![]() |
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Large abscesses are walled-off collections of pus and bacteria that often do not respond to antibiotic therapy. Standard of care involves percutaneous placement of indwelling catheter(s) for drainage, a long and uncomfortable process with high rehospitalization rates. The long-term goal of this work is to develop therapeutic ultrasound approaches to eradicate bacteria within abscesses as a noninvasive therapeutic alternative. Inertial cavitation induced by short pulses of focused ultrasound (histotripsy) is known to generate lethal mechanical damage in bacteria. Prior studies with Escherichia coli (E. coli) in suspension demonstrated that bactericidal effects increase with increasing peak negative amplitude, treatment time, and duty cycle. The current study investigated correlates of bactericidal activity with histotripsy cavitation cloud size. Histotripsy was applied to E. coli suspensions in 10-mL sample vials at 810 kHz, 1.2 MHz, or 3.25 MHz for 40 min. The cavitation activity in the sample vials was separately observed with high-speed photography. The cavitation cloud area was quantified from those images. A linear relationship was observed between bacterial inactivation and cavitation cloud size ( R2 = 0.98 ), regardless of the acoustic parameters (specifically frequency, pulse duration, and power) used to produce the cloud. |
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Development of an automated ultrasound signal indicator of lung interstitial syndrome Khokhlova, T.D., G.P. Thomas, J. Hall, K. Steinbock, J. Thiel, B.W. Cunitz, M.R. Bailey, L. Anderson, R. Kessler, M.K. Hall, and A.A. Adedipe, "Development of an automated ultrasound signal indicator of lung interstitial syndrome," J. Ultrasound Med., EOR, doi:10.1002/jum.16383, 2023. |
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5 Dec 2023 ![]() |
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The number and distribution of lung ultrasound (LUS) imaging artifacts termed B-lines correlate with the presence of acute lung disease such as infection, acute respiratory distress syndrome (ARDS), and pulmonary edema. Detection and interpretation of B-lines require dedicated training and is machine and operator-dependent. The goal of this study was to identify radio frequency (RF) signal features associated with B-lines in a cohort of patients with cardiogenic pulmonary edema. A quantitative signal indicator could then be used in a single-element, non-imaging, wearable, automated lung ultrasound sensor (LUSS) for continuous hands-free monitoring of lung fluid. |